Last edited by Faek
Tuesday, July 21, 2020 | History

5 edition of Lymphocyte Homing to the Skin found in the catalog.

Lymphocyte Homing to the Skin

Immunology, Immunopathology, and Therapeutic Perspectives

by Wolf-Henning Boehncke

  • 175 Want to read
  • 30 Currently reading

Published by Informa Healthcare .
Written in English

    Subjects:
  • Biology, Life Sciences,
  • Medical,
  • Medical / Nursing,
  • Dermatology,
  • Medical / Dermatology,
  • Immunology,
  • Cells,
  • Inflammation,
  • Skin,
  • T cells

  • The Physical Object
    FormatHardcover
    Number of Pages224
    ID Numbers
    Open LibraryOL11559551M
    ISBN 100849325285
    ISBN 109780849325281

      Lymphocyte homing from blood into tissues is mediated by a series of sequential interactions between the lymphocyte and the vascular endothelium in specialized postcapillary venules. Tissue specificity is imparted by the use of different combinations of adhesion and chemoattractant receptors at distinct anatomical sites. CTCLs usually express the cutaneous lymphocyte- homing receptor 54 as well as the chemokine receptor CCR4, often in combination with CCR10 and/or CXCR3. The expression of these receptors, not only on tumor cells residing in the skin but also on circulating cells, permits these cells to home effectively to the skin. Interestingly.

    Lymphocyte homing from blood into tissues is mediated by a series of sequential interactions between the lymphocyte and the vascular endothelium in specialized postcapillary venules ().Tissue specificity is imparted by the use of different combinations of adhesion and chemoattractant receptors at distinct anatomical sites. Intraepidermal lymphocytes in the skin. Lymphocytes in the dermis. Skin homing T cells express CLA. Chemokines and migration. Initiation of an immune response in the skin. Cytokines. Psoriasis, inflammation and autoreactive T cells. Autoimmune‐mediated diseases of the skin. Systemic diseases that affect the skin. Infectious diseases of the.

    Picker L.J., Treer J.R., Ferguson-Darnell B., Collins P.A., Bergstresser P.R., Terstappen L.W. () Control of lymphocyte reeirculation in man. II. Differential regulation of the cutaneous lymphocyte-assoeiated antigen, a tissue-selective homing receptor for skin-homing T cells. J Immunol – PubMed Google Scholar. Several homing molecules have been identified orchestrating extravasation of immune cells to certain peripheral non-lymphoid tissues such as gut, lung and skin. Regarding lymphocyte homing to skin.


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Lymphocyte Homing to the Skin by Wolf-Henning Boehncke Download PDF EPUB FB2

The book begins with a review of the role of T-lymphocytes in skin biology, followed by coverage of the process of lymphocyte recruitment, and lymphocyte homing to the skin. Subsequent chapters describe in vitro techniques to investigate lymphocyte extravasation, in vivo methods to study lymphocyte homing to the skin, and cutaneous T-lymphocytic infiltrates in skin : Hardcover.

DOI link for Lymphocyte Homing to the Skin. Lymphocyte Homing to the Skin book. Immunology, Immunopathology, and Therapeutic Perspectives. Edited By Wolf-Henning Boehncke.

Edition 1st Edition. First Published eBook Published 28 December Pub. location Boca Raton. Imprint CRC : Wolf-Henning Boehncke. The book begins with a review of the role of T-lymphocytes in skin biology, followed by coverage of the process of lymphocyte recruitment, and lymphocyte homing to the skin.

Subsequent chapters describe in vitro techniques to investigate lymphocyte extravasation, in vivo methods to study lymphocyte homing to the skin, and cutaneous T-lymphocytic infiltrates in Lymphocyte Homing to the Skin book pathology. Lymphocyte Homing to the Skin by Wolf-Henning Boehncke,available at Book Depository with free delivery : Wolf-Henning Boehncke.

Highlighting key findings in the field, Lymphocyte Homing to the Skin: Immunology, Immunopathology, and Therapeutic Perspectives brings insight to the physiology and pathophysiology of T-cell homing as a process, as well as to the manipulation of this process for therapeutic benefit.

The book begins with a review of the role of T-lymphocytes in skin biology, followed by coverage of the process of lymphocyte Author: Boehncke, Wolf-Henning. The identification of a lymphocyte homing receptor for skin may permit novel approaches to the diagnosis and therapy of cutaneous and inflammatory disorders.

While migration pattern of lymphocytes depends on subtype, polarization, and pathophysiological mechanisms, some T lymphocyte may also display tissue-specific homing properties. For example, T cells primed in Peyer’s patches (intestinal mucosa-associated secondary lymphoid tissue) receive a special addressing signal by the DC activating them.

This adhesion process is called lymphocyte homing. Lymphocyte Homing to Skin and Peripheral Tissues. Homing is the process by which circulating lymphocytes adhere to specialized endothelial cells within lymphoid organs.

The process is facilitated by two main mediators: Tissue-specific adhesion molecules on lymphocytes (homing receptors.). Rivino et al. examined individuals with natural dengue infection to determine whether skin-mediated immunity indeed contributes to the fight against dengue.

They found that dengue infection induced highly activated CD8+ T cells that express the skin-homing marker cutaneous lymphocyte-associated antigen (CLA). Summary: "Providing an update on T-cell homing, this book clarifies our understanding of this complex process and offers guidance on potential therapies.

It fulfills the needs of those involved in skin biology, skin toxicology, and dermatology, and proposes new directions for innovative research."--BOOK JACKET.

Highlighting key findings in the field, Lymphocyte Homing to the Skin: Immunology, Immunopathology, and Therapeutic Perspectives brings insight to the physiology and pathophysiology of T-cell homing a.

Skin. Lymphocyte homing to skin under conditions of acute inflammation (e.g. during contact hypersensitivity responses) or chronic inflammation (e.g.

psoriasis) has grown increasingly well characterized (Section ). By contrast, the circumstances under which lymphocytes migrate into non-inflamed skin are difficult to study and less well understood, in large part because this.

Multi-step homing mechanism for T eff cell recruitment to the skin. T eff cells primed by Ag in regional LN draining skin (not shown) become imprinted with skin homing molecules, among which include adhesive glycoproteins CLA and CD43E, chemokine receptors CCR4 (Th2) and CCR10 (Th22), and integrins LFA-1 and VLA (Step 1) Circulating T eff cells in postcapillary venules of the dermis tether.

Background: In nonimmediate cutaneous reactions to drugs, the skin is the organ most frequently involved, and T cells may play a relevant role.

T cells related to skin immune responses express the cutaneous lymphocyte-associated antigen (CLA), the.

LYMPHOCYTE HOMING TO THE: Lymphocyte Homing to the Skin: Immunology, Immunopathology, and Therapeutic Perspectives. Picker LJ, Treer JR, Ferguson-Darnell B, Collins PA, Bergstresser PR, Terstappen LWMM () Control of lymphocyte recirculation in man.

III. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue selective homing receptor for skin-homing T. CLA-E-selectin is the first adhesion step in migration, followed by very late antigen-4 (VLA-4) and lymphocyte-associated antigen 1 (LFA-1) attachment to activated endothelium and further lymphocyte transmigration to inflamed skin [20,21].

CLA has been recognized as one of the most important skin-homing molecules and its expression in activated lymphocytes can affect cell composition of the. A skin-associated population of memory T lymphocytes, defined by expression of the cutaneous lymphocyte antigen (CLA), binds selectively and avidly to the vascular lectin endothelial cell-leukocyte adhesion molecule 1 (ELAM-1), an interaction that may be involved in targeting of CLA+ T cells to cutaneous sites of chronic inflammation.

Multi-step homing mechanism for T eff cell recruitment to the skin T eff cells primed by Ag in regional LN draining skin (not shown) become imprinted with skin homing molecules, among which include adhesive glycoproteins CLA and CD43E, chemokine receptors CCR4 (Th2) and CCR10 (Th22), and integrins LFA-1 and VLA Skin specific homing - Acts as a method of recruiting a large number of memory T cells to the skin, which poses a high risk of infection.

Again this involves the expression of different integrins. In this case, in humans α4β1 and cutaneous lymphocyte antigen (CLA) are expressed on the T cell surface.

Lymphocyte homing receptors are cell adhesion molecules expressed on lymphocyte cell membranes that recognize addressins on target tissues. Lymphocyte homing refers to adhesion of the circulating lymphocytes in blood to specialized endothelial cells within lymphoid organs.

These diverse tissue-specific adhesion molecules on lymphocytes (homing receptors) and on endothelial cells (vascular.Tissue-Specific Lymphocyte Homing. Cutaneous lymphocyte-associated antigen (CLA +) T lymphocytes, which home to skin, preferentially express CCR4 and CCR 24 The CCR4 ligand CCL22 is made by resident dermal macrophages and DCs, whereas the CCR10 ligand CCL27 is made by keratinocytes.

Blocking both these pathways, but not either one alone, has been reported to inhibit lymphocyte. Background: In nonimmediate cutaneous reactions to drugs, the skin is the organ most frequently involved, and T cells may play a relevant role. T cells related to skin immune responses express the cutaneous lymphocyte‐associated antigen (CLA), the skin‐homing receptor.

Methods: We studied the expression of the CLA in peripheral blood T cells from nine subjects with exanthematous .